Mode of action
According to the anticoccidial properties of triazinones, diclazuril is active against Intracellular development stages of coccidia, namely during schizogony and gametogony.
After diclazuril treatment, the first- and second generation schizonts show extensive Degenerative changes, which are characterised by the loss of internal structure, the appearance of many intracytoplasmic vacuoles and incomplete merogony.
This leads to complete Degeneration of schizonts and gamonts.
Low load on liver and kidney due to 73 % of the dose was recovered in the excreta 48 hours after dosing (70 % in the feces and 3 % in the urine) and 98 % after ten days (91 % in feces and 7 %in urine, respectively).
Bile radioactivity was very low which precludes enterohepatic circulation
[/vc_column_text][/vc_tta_section][vc_tta_section title=”Indication” tab_id=”1456087298145-b8cc9843-08d3″][vc_column_text]coccediosis out break[/vc_column_text][/vc_tta_section][vc_tta_section title=”Dosage and Administration” tab_id=”1456087335331-1a59ff2a-2a82″][vc_column_text]
- Treatment dose :0.5 ml / 1 liter of drinking water for two Successive days
- Prophylactic dose: (.25 ml / 1 liter)